Engineering DNA nanostructure-based artificial biological systems for biomedical applications.
Yi Chen's research focuses on the precise engineering of biologic functional components on the nanometer scale. By using the unprecedented engineering abilities of DNA nanotechnology, Chen's research is dedicated to establishing a research platform to understand fundamental physiological mechanisms at the molecular level, and develop novel medical applications such as efficient targeted drug delivery and tissue engineering. His research is highly interdisciplinary, involving chemistry, materials science and engineering, biotechnology, nanomanufacturing and translational medicine.
Dr. Yi Chen is an assistant professor of nanoengineering at UC San Diego. His research focuses on the precise engineering of biological functional components on the nanometer scale for medical applications. Chen was a postdoctoral associate at David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology during 2010-2014, where his research focused on developing new materials using DNA nanotechnology for drug delivery. He received his Ph.D. in Chemistry from Purdue University in 2008. His Ph.D. research involved DNA nanomachines, hybrid nanomaterials and two- and three-dimensional DNA arrays. He has two patents, three book chapters and over 26 peer-reviewed publications, several of which have been published in prestigious journals like Nature, Nature Nanotechnology, Angewandte Chemie International Edition and JACS.