UC San Diego Materials Science and Engineering


Ratnesh  Lal

Ratnesh Lal


Mechanical & Aerospace Engineering


Phone: 858-822-0384

Nanobiotechnology, multidimensional biological atomic force microscopy, ion channel biophysics and nanomedicine.

Professor Lal is an authority on biomedical applications of atomic force microscopy (AFM) and nanoscale imaging of complex biological systems. Research in his lab involves the development of nanotechnologies for and multi-scale biophysical and system biology studies of channels and receptors. His lab also designs nanosensors and devices for biomedical diagnostics and therapeutics. Current projects include i) structure-function study of hemichannels in heart, breast and liver, ii) structure-function study of amyloid ion channels in degenerative diseases, iii)) nanomechanical properties, cytoskeletal organization and sustenance of normal and abnormal cells, iv) designing multimodal 'Smart AFM' integrating AFM, Optical Tweezers, electrical recording, and single molecule microscopy, and v) designing nanodevices and BioMEMs for array-based screening of therapeutics and their delivery and tissue engineering.

Professor Lal received his MS and Masters of Philosophy in Physics and Biophysics from JNU in New Delhi and his Ph.D. in Neurobiology from the University of Alabama. After postdoctoral training at Caltech, he was a faculty member at the University of Chicago and the University of California at Santa Barbara. Before assuming his current position at UCSD, he was a Professor and the Director of the newly established Center of Nanomedicine at the University of Chicago.