Gene Yeo

Cellular and Molecular Medicine


Research Focus
Post-transcriptional processing of RNAs by multiple mechanisms, examining how defects in protein-RNA complexes lead to human disease, altering gene regulatory circuits in mammalian cells by manipulating RNA processing using modular assemblies of proteins or protein-RNA complexes

Research Summary

A major focus of the Yeo lab is to understand how gene expression is controlled at the RNA level to maintain the proper functioning of cells during development and aging. Over the past decade, there has been a dramatic increase in the recognition that members of a broad class of proteins termed RNA binding proteins (RBPs) are crucial for maintaining molecular and cellular homeostasis. RBPs regulate processes such as cell survival, pluripotency of embryonic stem cells, and neuronal function, as well as aid in the transition between cellular states in response to stimuli, such as during neural specification of stem cells, cellular stresses, or viral infections.

Gene Yeo
Lab Website


Gene Yeo Ph.D. MBA is a Professor of Cellular and Molecular Medicine at the University of California San Diego (UC San Diego), a founding member of the Institute for Genomic Medicine, and a member of the UC San Diego Stem Cell Program and Moores Cancer Center. Dr. Yeo has a BSc in Chemical Engineering and a BA in Economics from the University of Illinois, Urbana-Champaign, a Ph.D. in Computational Neuroscience from Massachusetts Institute of Technology, and an MBA from the UCSD Rady School of Management. Dr. Yeo serves as Co-Director of the Bioinformatics and Systems Biology Graduate Program, an Associate Director of a Genetics T32 training program at UC San Diego, and Deputy Scientific Director of Sanford Consortium for Regenerative Medicine in La Jolla.